Publications

You can also find my articles on my Google Scholar profile.

Effects of tDCS on spontaneous spike activity in a healthy ambulatory rat model

Published in Brain Stimulation, 2020

We tested whether transcranial direct-current stimulation (tDCS) had any effect on the spike rate or LFP content in ambulatory rats using a within-subject design to test anodal, cathodal, and sham stimulation cases. Read more

Recommended citation: Milighetti, S., Sterzi, S., Fregni, F., Hanlon, C. A., Hayley, P., Murphy, M. D., Nudo R. J., Guggenmos, D. J. (2020). Effects of tDCS on spontaneous spike activity in a healthy ambulatory rat model. Brain Stimulation, 13(6), 1566-1576. https://www.sciencedirect.com/science/article/pii/S1935861X20302345/pdfft?isDTMRedir=true&download=true

Differential effects of open-and closed-loop intracortical microstimulation on firing patterns of neurons in distant cortical areas

Published in Cerebral cortex, 2020

Intracortical microstimulation (ICMS) was applied to the rat primary sensory cortex in healthy anesthetized rats using both closed- and open-loop paradigms. Changes in firing rates and regimes were tested over the course of a few hours to determine if an effect differentiating the protocols could be detected during this time. Read more

Recommended citation: Averna, A., Pasquale, V., Murphy, M. D., Rogantin, M. P., Van Acker, G. M., Nudo, R. J., Guggenmos, D. J. (2020). Differential effects of open-and closed-loop intracortical microstimulation on firing patterns of neurons in distant cortical areas. Cerebral Cortex, 30(5), 2879-2896. https://academic.oup.com/cercor/article/30/5/2879/5673779

Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat

Published in PLoS ONE, 2019

Rats were trained on a gross (lever-press) and fine (pellet-retrieval) forelimb task, implanted with microwire arrays spanning unilateral sensorimotor cortex contralateral to the moving limb, and then tested over the course of days and weeks to determine the longitudinal stability of both spiking unit signals as well as gamma LFP in this context. Read more

Recommended citation: Bundy, D. T., Guggenmos, D. J., Murphy, M. D., Nudo, R. J. (2019). Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat. PloS one, 14(10), e0219034. https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0219034&type=printable

Improving an open-source commercial system to reliably perform activity-dependent stimulation

Published in Journal of Neural Engineering, 2019

We modified the Intan Stimulation/Recording controller to deliver closed-loop stimulation using a finite state machine to improve artifact rejection, such as may occur due to electrical microstimulation or other physiological events such as chewing and whisking. Read more

Recommended citation: Murphy, M., Buccelli, S., Bornat, Y., Bundy, D., Nudo, R., Guggenmos, D., Chiappalone, M. (2019). Improving an open-source commercial system to reliably perform activity-dependent stimulation. Journal of neural engineering, 16(6), 066022. http://m053m716.github.io/files/Murphy_et_al__2019__Improving_an_open-source_commercial_system_to_reliably_perform_activity_dependent_stimulation.pdf

Assessing Perturbations to Neural Spiking Response Dynamics Caused By Electrical Microstimulation

Published in International Symposium on Circuits and Systems, 2018

This paper is about a proof-of-concept nonlinear dynamical systems approach applied to peri-stimulus epochs to see if it could detect longitudinal differences in how open- and closed-loop influence the system response to electrical microstimulation of sensory cortex in ambulatory rats. Read more

Recommended citation: Murphy, M. D., Dunham, C., Nudo, R. J., Guggenmos, D. J., Averna, A. (2018, May). Assessing Perturbations to Neural Spiking Response Dynamics Caused By Electrical Microstimulation. In 2018 IEEE International Symposium on Circuits and Systems (ISCAS) (pp. 1-5). IEEE. https://ieeexplore.ieee.org/iel7/8334884/8350884/08351872.pdf

Comprehensive spatial analysis of the Borrelia burgdorferi lipoproteome reveals a compartmentalization bias toward the bacterial surface

Published in Journal of Bacteriology, 2017

This paper is about the localization of lipoproteins to a particular side and layer of the bilayer membrane of Borrelia, the causative agent of Lyme disease. It is a descriptive study that catalogues this specific property of each putative lipoprotein identified in the Borrelia lipoproteome. Read more

Recommended citation: Dowdell, A. S., Murphy, M. D., Azodi, C., Swanson, S. K., Florens, L., Chen, S., Zuckert, W. R. (2017). Comprehensive spatial analysis of the Borrelia burgdorferi lipoproteome reveals a compartmentalization bias toward the bacterial surface. Journal of bacteriology, 199(6). https://jb.asm.org/content/jb/199/6/e00658-16.full.pdf

Current challenges facing the translation of brain computer interfaces from preclinical trials to use in human patients

Published in Frontiers in Cellular Neuroscience, 2016

This is a review of the challenges facing the translation of brain computer interfaces from preclinical trials to widespread use in the clinic. There is an emphasis on activity-dependent stimulation and similar paradigms. Read more

Recommended citation: Murphy, M. D., Guggenmos, D. J., Bundy, D. T., Nudo, R. J. (2016). Current challenges facing the translation of brain computer interfaces from preclinical trials to use in human patients. Frontiers in cellular neuroscience, 9, 497. https://www.frontiersin.org/articles/10.3389/fncel.2015.00497/pdf

Max Murphy